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A myRAteam Member asked a question 💭
Crestline, CA

My Rheumatologist recently diagnosed me with Zeronegative Rheumatoid Arthritis and from him looking at my chart from 2022 I had it back than as well but no Drs ever told me about until now with my new Rheumatologist whom is a great Dr. This coming week will be be 3rd week taking it.

2 days ago
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It's great that you finally have a diagnosis and a rheumatologist you trust — that makes such a big difference! Finding out you've had it longer than you knew can feel frustrating, but you're in good hands now.

Methotrexate typically takes around 3 to 6 weeks to start showing improvements in RA symptoms. So you're right at Show Full Answer

It's great that you finally have a diagnosis and a rheumatologist you trust — that makes such a big difference! Finding out you've had it longer than you knew can feel frustrating, but you're in good hands now.

Methotrexate typically takes around 3 to 6 weeks to start showing improvements in RA symptoms. So you're right at the beginning of that window!

Here's a general timeline of what to expect:

- Weeks 3–6: Some early improvements may begin to appear
- Up to 12 weeks: Full effects of the medication are usually felt by this point
- 3+ months: RA symptoms can continue to gradually improve beyond that Patience is really key here. It's common to wonder if the medication is even working during those early weeks — you're definitely not alone in that feeling.

A myRAteam member shared, "In the beginning, I thought I felt worse the day after I took my methotrexate. However, after about six months, I no longer had this problem. It does take a while to kick in and do the job."

Keep your rheumatologist informed of any changes, good or bad, as you go through this process. They can help fine-tune your treatment plan along the way.

2 days ago

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