It's completely understandable to feel frustrated when you're not seeing results yet — especially while dealing with upper leg pain and weakness. Hang in there!
Methotrexate typically takes 3 to 6 weeks to start improving RA symptoms, and it can take up to 12 weeks to feel the full effects. Since you've had to pause it a Show Full Answer
It's completely understandable to feel frustrated when you're not seeing results yet — especially while dealing with upper leg pain and weakness. Hang in there!
Methotrexate typically takes 3 to 6 weeks to start improving RA symptoms, and it can take up to 12 weeks to feel the full effects. Since you've had to pause it a couple of times for antibiotics, this may have slowed down that timeline a little. Here are a few things worth knowing and discussing with your doctor:
- Stopping and restarting methotrexate can affect how consistently it works, so let your rheumatologist know about the interruptions
- Upper leg pain and weakness could be related to RA inflammation — worth flagging with your doctor if it's new or worsening
- Folic acid is commonly recommended alongside methotrexate to help reduce side effects like fatigue and stomach issues
It's really important to be patient with methotrexate, as many people with RA do notice improvement over time. That said, always keep your rheumatologist in the loop about how you're feeling — they may want to adjust your plan.
October 11
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