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A myRAteam Member asked a question πŸ’­
Oklahoma City, OK

Sero-positive RA in Sept 2025. Been through Plaquenil, Sulfasalizine and Methotrexate...WBC stays low, markers high. Just want something to work...

August 15
 · 
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myRAteam

It's completely understandable to feel nervous after reading a side effects list β€” they can look terrifying on paper! Hyrimoz is a biosimilar to Humira, a well-established biologic that many people with RA have used for years. Given that Plaquenil, Sulfasalazine, and Methotrexate haven't brought your markers down, moving to Show Full Answer

It's completely understandable to feel nervous after reading a side effects list β€” they can look terrifying on paper! Hyrimoz is a biosimilar to Humira, a well-established biologic that many people with RA have used for years. Given that Plaquenil, Sulfasalazine, and Methotrexate haven't brought your markers down, moving to a biologic is a very logical next step.

Here's some reassurance about side effect lists for biologics:

- Early reports of side effects often reflect people with more severe RA, who are already at higher risk
- As biologics get used more widely, the average risk of serious side effects tends to look lower over time
- Serious side effects are possible but relatively rare β€” common ones are more like upper respiratory infections, headaches, or stomach issues

That said, real risks do exist and are worth knowing about:

- Increased chance of serious infections (important given your already-low WBC)
- Small increased risk of blood clots or certain cancers
- These risks vary based on your individual health picture Because your white blood cell count has been running low, it's especially important to have an open conversation with your rheumatologist before starting. Make sure they're aware of your WBC history so they can monitor you closely and set up a safe plan.

Keeping a journal of any new symptoms once you start can also help you track and report changes clearly at appointments. Wishing you real relief β€” you deserve something that finally works! πŸ’™

August 15

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