How often should RF and Anti-CCP be measured? I decided on my own to run these tests now because I'm starting a new treatment, but in 7 years my doctor has never ordered them. He only relies on ESR and CRP every 4 months, which are always in range. I just found out through myRAteam resources that I am seropositive. Would love to hear what others experience with their doctors!
May 28
A significant rise in anti-CCP levels like this is understandably concerning, and it's a really important thing to discuss with your rheumatologist as soon as possible.
Anti-CCP antibodies are strongly associated with RA activity. Higher levels are often linked to more severe disease and can influence treatment decisions Show Full Answer
A significant rise in anti-CCP levels like this is understandably concerning, and it's a really important thing to discuss with your rheumatologist as soon as possible.
Anti-CCP antibodies are strongly associated with RA activity. Higher levels are often linked to more severe disease and can influence treatment decisions in a few key ways:
- Treatment urgency — High anti-CCP levels may prompt your doctor to recommend starting or adjusting to a more aggressive treatment sooner
- Treatment type — Elevated anti-CCP combined with high rheumatoid factor (RF) may influence which biologics or DMARDs are most appropriate, such as TNF inhibitors
- Disease severity — A positive anti-CCP at high levels is associated with a greater likelihood of joint damage and extra-articular symptoms (symptoms outside the joints)
It's worth noting that anti-CCP levels alone don't tell the whole story. Your doctor will also look at inflammation markers like CRP and ESR, joint counts, imaging, and how you're feeling overall. As for others experiencing this — yes! Several myRAteam members have shared that their blood markers have shifted significantly over time, especially before starting or changing biologics. Many have noted that rising markers prompted their doctors to adjust their treatment plans.
This kind of change in your numbers is exactly the type of information your rheumatologist needs to reassess your current treatment and make sure it's still the right fit for you. Don't wait on that conversation! 💪
May 28
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