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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myRAteam Member asked a question 💭
Fort Dodge, IA
May 11
 · 
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Yes, a cough can be a side effect of methotrexate, and you're definitely not alone in experiencing this. It's actually one of the signs that may suggest your body is dealing with an infection, which can happen because methotrexate suppresses the immune system.

Other related symptoms to watch for include:

- Stuffy or runny Show Full Answer

Yes, a cough can be a side effect of methotrexate, and you're definitely not alone in experiencing this. It's actually one of the signs that may suggest your body is dealing with an infection, which can happen because methotrexate suppresses the immune system.

Other related symptoms to watch for include:

- Stuffy or runny nose
- Sneezing
- Ear congestion
- Hoarseness
- Bloody nose
- Ringing or buzzing in the ears
- Loss of hearing These types of side effects affect around 10% of people taking methotrexate. Because methotrexate lowers your immune system's ability to fight off infections, it's really important to let your rheumatologist know about a cough as soon as possible — especially if it lingers or gets worse.

Never stop or adjust your methotrexate dose on your own without speaking to your doctor first. They can help figure out whether the cough is a side effect, an infection, or something that needs a change in your treatment plan.

May 11

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