Can you take anti-inflammatory drugs like naproxen with methotrexate?
It's not that you absolutely cannot take them together, but there are important considerations. Many people with rheumatoid arthritis do take both methotrexate and NSAIDs (nonsteroidal anti-inflammatory drugs) like naproxen together.
However, combining Show Full Answer
Can you take anti-inflammatory drugs like naproxen with methotrexate?
It's not that you absolutely cannot take them together, but there are important considerations. Many people with rheumatoid arthritis do take both methotrexate and NSAIDs (nonsteroidal anti-inflammatory drugs) like naproxen together.
However, combining them can potentially lead to higher methotrexate levels in your body and increase the risk of side effects. This is especially true at higher doses of methotrexate.
Your physician should review your NSAID use and methotrexate dosing to determine if it's safe for you to take these together. The combination might also increase your risk of stomach bleeding.
Since you're taking naproxen daily, it's important to discuss this with your doctor. They can monitor you appropriately and adjust dosages if needed to keep you safe while managing your symptoms effectively.
December 28, 2025
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