Are there other treatment options if Actemra or its biosimilar Tyenne is causing monthly colds and severe mouth ulcers?
Getting frequent infections and mouth ulcers is challenging. These symptoms suggest your immune system may be suppressed from the medication, making you more vulnerable to infections and sores.
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Are there other treatment options if Actemra or its biosimilar Tyenne is causing monthly colds and severe mouth ulcers?
Getting frequent infections and mouth ulcers is challenging. These symptoms suggest your immune system may be suppressed from the medication, making you more vulnerable to infections and sores.
It's important to talk with your rheumatologist about these side effects. They can work with you to find alternative treatments that manage your RA symptoms while reducing these issues.
Here are some options your doctor might consider:
• Switching to a different biologic medication that may not cause the same side effects
• Adjusting your current dosage
• Trying a different class of disease-modifying drugs (DMARDs)
• Adding folic acid supplements if you're also taking methotrexate, as this can reduce mouth sores by up to 79 percent
While managing these symptoms, you might find relief from mouth ulcers by:
• Using alcohol-free mouth rinses or saltwater rinses
• Asking your doctor about prescription mouthwashes containing lidocaine
• Trying "magic mouthwash" (BLM mouthwash), which some members have found helpful
A myRAteam member shared: "Unfortunately, with the immune system suppression from medication, it can cause blisters and sores."
Don't stop or change your medication without consulting your doctor first. They'll help find the right treatment balance for you.
November 26, 2025
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