Can methotrexate cause bladder issues?
Yes, methotrexate can cause some bladder-related symptoms, though they're less common side effects. You might experience:
- Burning sensation while urinating
- Blood in the urine
- Dark-colored urine
These symptoms may or may not be associated with a urinary tract infection (UTI).
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Can methotrexate cause bladder issues?
Yes, methotrexate can cause some bladder-related symptoms, though they're less common side effects. You might experience:
- Burning sensation while urinating
- Blood in the urine
- Dark-colored urine
These symptoms may or may not be associated with a urinary tract infection (UTI).
It's important to understand that methotrexate weakens the immune system, which helps reduce RA inflammation but also makes you more vulnerable to infections like UTIs. Research has shown that people with RA taking methotrexate have a higher risk of developing infections, including UTIs.
If you're experiencing any urinary symptoms, don't wait to address them. Contact your doctor right away so they can determine whether you have a UTI or if it's a medication side effect. Early treatment is crucial to prevent complications like kidney or bladder infections.
Your rheumatologist may temporarily pause your methotrexate while treating any infection to help your immune system fight it off more effectively.
November 24, 2025
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