Can methotrexate cause numbness and tingling in the feet?
Yes, rarely methotrexate can cause numbness and tingling in the feet, hands, or lips. This happens because methotrexate blocks your body's ability to use folate (an essential vitamin), and low folate levels can lead to nerve-related problems.
If you're experiencing Show Full Answer
Can methotrexate cause numbness and tingling in the feet?
Yes, rarely methotrexate can cause numbness and tingling in the feet, hands, or lips. This happens because methotrexate blocks your body's ability to use folate (an essential vitamin), and low folate levels can lead to nerve-related problems.
If you're experiencing these symptoms, it's important to contact your rheumatologist or healthcare provider right away. Numbness and tingling may be signs of serious side effects that can often be corrected if treated promptly.
Your doctor may recommend folic acid supplementation, which is often used to help alleviate various side effects of methotrexate including nerve-related issues, fatigue, headache, and stomach problems.
Keep in mind that tingling and numbness can also be caused by rheumatoid arthritis itself through a condition called peripheral neuropathy, so your doctor will need to determine the actual cause of your symptoms.
November 15, 2025
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