Six months into Methotrexate I developed Pneumonitis . It was a terrible and frightening experience and why I will never take it again . I have been fine for years on Sulfasaliazine .
October 27, 2025
Can methotrexate cause lung problems in people with rheumatoid arthritis?
Yes, methotrexate can cause lung complications, though this is considered a rare but serious side effect. The medication may lead to lung inflammation or fibrosis (scarring of lung tissue). Signs to watch for include a new cough or shortness of Show Full Answer
Can methotrexate cause lung problems in people with rheumatoid arthritis?
Yes, methotrexate can cause lung complications, though this is considered a rare but serious side effect. The medication may lead to lung inflammation or fibrosis (scarring of lung tissue). Signs to watch for include a new cough or shortness of breath.
Because of this risk, methotrexate is not recommended for people who already have existing lung disease before starting treatment.
It's important to note that rheumatoid arthritis itself can also cause lung problems independent of medication. Lung complications occur in 30 to 40 percent of people with RA and include conditions like:
- Interstitial lung disease (inflammation and scarring)
- Pulmonary nodules
- Pleural effusion (fluid accumulation)
- Bronchiectasis (airway damage)
Your doctor will monitor you closely with regular check-ups and blood tests while you're taking methotrexate. If you develop any respiratory symptoms like coughing or difficulty breathing, contact your rheumatologist right away. They can evaluate whether the symptoms are related to the medication and adjust your treatment plan if needed.
October 25, 2025
Join
Your Privacy Choices
