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Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

have both RA and Sjogren’s. Does anyone else suffer from mouth sores, or sore patches on their tongue? I’m taking Plaquinel and Leflunomide.

A myRAteam Member asked a question 💭
Birmingham, AL

have both RA and Sjogren’s. Does anyone else suffer from mouth sores, or sore patches on their tongue? I’m taking both Plaquinel and Leflunomide. I was on Remicade infusions every 7 weeks, but had to stop because I couldn’t afford the copayments. I can tell that I’m worse without the infusions.

April 21, 2025
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A myRAteam Member

I have Ra and Sjorgens and get a sore mouth and gums.
I get a mouth spray called Difflam from my GP. It works for me. Or you could try warm water with salt in and rinse your mouth out with it
Works for me.
I'm from Birmingham England..

April 22, 2025
myRAteam

Mouth sores and tongue discomfort are commonly reported by people taking RA medications. Disease-modifying antirheumatic drugs (DMARDs) like Leflunomide can sometimes cause these symptoms because they suppress the immune system. Many myRAteam members have shared similar experiences with mouth sores while taking RA Show Full Answer

Mouth sores and tongue discomfort are commonly reported by people taking RA medications. Disease-modifying antirheumatic drugs (DMARDs) like Leflunomide can sometimes cause these symptoms because they suppress the immune system. Many myRAteam members have shared similar experiences with mouth sores while taking RA medications.

Common symptoms include pain, soreness, discomfort when eating spicy or hot foods, and trouble chewing. Some people experience blistering or breaks in the skin of the mouth and tongue. If you're experiencing mouth sores, it's important to contact your healthcare provider, especially if:
- The sores appear after starting a medication
- You have large white patches on your tongue or roof of mouth
- The sores interfere with taking your medication
- You have constant discomfort

Your doctor can help determine if the sores are medication-related and suggest ways to manage them while maintaining your RA treatment plan.

April 21, 2025
A myRAteam Member

Thank you, Judy! I’m from Birmingham Alabama! 🤗

April 23, 2025

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