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Yes, there is a connection. People with RA are about eight times more likely to develop lung disease than the general population. Lung complications are actually one of the most common symptoms of RA that occur outside of joint problems. Regarding methotrexate specifically, while it's an effective medication for RA, it can Show Full Answer

Yes, there is a connection. People with RA are about eight times more likely to develop lung disease than the general population. Lung complications are actually one of the most common symptoms of RA that occur outside of joint problems. Regarding methotrexate specifically, while it's an effective medication for RA, it can affect the lungs in rare cases. Less than 1% of people taking methotrexate may experience lung injury. Because of this risk, methotrexate is typically not recommended for people who already have existing lung disease. If you develop any cough or shortness of breath while taking methotrexate, you should inform your doctor immediately.

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