Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
All Resources Treatments A-Z Personal Assistant Help Center Crisis
Powered By
Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Methotrexate

A myRAteam Member asked a question 💭
Greenville, MI

I started taking methotrexate last Friday (2/17) and I wondered if others feel a little rougher on day 2 post-meds more than day 1? This has been the case for me both last week and this week. Curious to hear others' experiences.

February 26, 2023
 · 
Reactions

Answer Summary

Members shared their personal experiences with methotrexate, with many confirming that day 2 after taking the medication tends to feel worse... Read more

Members shared their personal experiences with methotrexate, with many confirming that day 2 after taking the medication tends to feel worse than day 1, describing it as a 'methotrexate hangover' marked by fatigue, nausea, and a general blah feeling. Several members offered helpful strategies to manage side effects, including taking the medication at night, splitting the dose, drinking plenty of water, taking folic acid daily, and switching to injections to reduce stomach upset. A recurring theme was that side effects often improved over time, and that working closely with a rheumatologist to adjust the dose can make a big difference in tolerability.

A myRAteam Member

I did not do well with methotrexate. The side effects were challenging- extreme fatigue, no energy, depression, weight gain. I no longer use this med.

February 26, 2023
A myRAteam Member

Yes its the exact same way for me

February 26, 2023
A myRAteam Member

4 tabs Saturday and Sunday. Haven't noticed any problems.

February 26, 2023
A myRAteam Member

Hello, When I first started on methotrexate, I felt horrible the day after. I did not make any plans for that day so I could be a couch potato. It did eventually get better, but I really dreaded taking it at first. My doctor had me split it up on the day I take it. I take 5 in the afternoon and the other five before I go to bed. It seemed to have helped. Good luck to you! Tammie :)

October 25, 2023
A myRAteam Member

I took this for a very short period, it made me so sick. I was so tired, I didn't have any energy to just get out of bed. Wherever I took the shot, would swell up. This medication, was really bad for me.

March 13, 2023
Continue with Facebook
Continue with Google
By joining, you accept our Terms of Use, and acknowledge our collection, sharing, and use of your data in accordance with our Health Data and Privacy policies.
Already a member? Log In