Answer Summary

Members responded to someone experiencing new joint pain and fatigue after starting Hydroxychloroquine alongside methotrexate, with the most... Read more

Members responded to someone experiencing new joint pain and fatigue after starting Hydroxychloroquine alongside methotrexate, with the most common advice being that RA medications typically take several months to show improvement and that the worsening symptoms are more likely the disease itself rather than a reaction to the new drug. Several members shared mixed experiences with Hydroxychloroquine, including one who found life-changing relief within a month after losing range of motion, while others had to discontinue it due to eye problems, severe skin reactions, or lack of effectiveness, ultimately switching to alternatives like Rinvoq. A recurring theme was the importance of patience, allowing 4 to 6 months for medications to work, staying in close communication with your doctor about any concerning symptoms, and remembering that not every medication works for everyone.