I took just Enbrel with an NSAID for 19 years. Perhaps your doctor will reduce your medications. But we are all different. Nancy

Hydroychlorquine can affect your eyes if you have any problem with certain eye problems, I took it for a year and had to stop, can cause high blood pressure too. Have been on methotrexate for 2 years, I also need it for my CLL as it is a cancer drug. I will probably be on it forever.

I was diagnosed with RA about 30 years ago and was put on methotrexate and folic acid (the latter a must if on methotrexate) for a number of years by a Rheumatologist and still had flare-ups. My GP took me off metho as that was contra-indicated for some of my other chronic meds and put on Celebrex and while it did prevent flares it did not reduce the RA progression. I had to stop Celebrex about 12 years ago when I had an aortic valve replacement. Long story short, I cannot take or use an anti-inflamatory or NSAID, irrespective of application. Speak to your Rheumatologist about stopping Methotrexate as it does have side-effects and Hydroxychloroqine is as effective but it also is not without side-effect or risk. Enbrel is also an auto-imune suppresent as are the other two and again has some risk and side-effects but I do not understand why you have been put on all 3. I would speak to more than the practitioner who put you on the meds about whether you should continue with all 3.

I just want to generally respond that when my Wife is on an antibiotic, she cannot take some of the RA drugs (just too much fun when this happens☹️).