Connect with others who understand.

Sign up Log in
Resources
About myRAteam
Powered By
Real members of myRAteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Remicade

A myRAteam Member asked a question 💭
Casper, WY

Hello
I have failed at so many meds....
I LOVED Rinvoq! however my liver did not! 😢
Immuran gave me pancreatitis and I spent a week in the hospital.
So I am now onto Remicade...anyone have success with this medication?
Pro’s & Con’s

February 1, 2021
•
View reactions
A myRAteam Member

Unfortunately Remicade did not work for me but did for a friend. Everyone is different and what works for you may not for me. For RA people it seems to be trial and error. So depressing.

February 1, 2021
myRAteam

Remicade, also known by its drug name infliximab, is a biologic disease-modifying antirheumatic drug (DMARD) approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe rheumatoid arthritis in combination with methotrexate. Here are some key points about Remicade:

Mechanism of Action
- Function: Show Full Answer

Remicade, also known by its drug name infliximab, is a biologic disease-modifying antirheumatic drug (DMARD) approved by the U.S. Food and Drug Administration (FDA) to treat moderate to severe rheumatoid arthritis in combination with methotrexate. Here are some key points about Remicade:

Mechanism of Action:
- Function: Remicade is a genetically engineered antibody.
- Target: It attaches to tumor necrosis factor alpha (TNF-α), a chemical messenger involved in autoimmune attacks.
- Action: By binding to TNF-α, Remicade prevents it from signaling the immune system to attack the body’s connective tissues.

Administration:
- Form: Available in vial form.
- Method: Administered as an intravenous infusion.
- Frequency: Every four or eight weeks after initial loading doses.

Side Effects:
- Common: Infections, infusion-related reactions, headache, and abdominal pain.
- Serious: Severe infections, increased risk for lymphoma, hepatitis B virus reactivation, liver damage, heart failure, low blood cell counts, lupus-like syndrome, and nerve damage.

Clinical Trials and Approval:
- ATTRACT Trial: A double-blind, placebo-controlled, randomized clinical trial involving 428 patients at 34 clinical sites. At week 30, 50% of patients treated with Remicade and methotrexate achieved an ACR 20 response criteria compared to 20% of patients receiving methotrexate alone.
- FDA Approval: Initially approved for use with methotrexate for rheumatoid arthritis. Later approved as a first-line treatment for moderate to severe rheumatoid arthritis based on the ASPIRE trial, which showed that early intervention with Remicade plus methotrexate was superior to methotrexate alone in preventing the progression of structural damage.

Additional Information:
- Biosimilar: Remsima is a biosimilar of Remicade, meaning it is highly similar to Remicade and works in the same way.

For more details, you can visit the following resources:
- [Remicade — Janssen](https://www.remicade.com/)
- [Remicade (Infliximab) for Rheumatoid Arthritis | myRAteam](https://www.myrateam.com/treatments/remicade)
- [Infliximab (Remicade) Receives FDA Approval for Rheumatoid Arthritis • Johns Hopkins Arthritis Center](https://www.hopkinsarthritis.org/arthritis-news...)
- [Infliximab Injection: MedlinePlus Drug Information](https://medlineplus.gov/druginfo/meds/a604023.html)

Always consult with your healthcare provider for personalized medical advice.

July 15, 2024
A myRAteam Member

Hasn’t worked for me. I’m doing my last infusion as I type. Starting Xeljanz as soon as the insurance approved it.

February 16, 2021
A myRAteam Member

i took remicade it worked great i was pain free but i was always very itchy a day later and i was very fatigued and during my treatments everything tasted like metal i did end up stoping it due to a allergy but it worked great when i was on it

February 14, 2021
A myRAteam Member

I haven't tried remecade but my daughter has ulcerative colitis and was on it and went into remission

February 8, 2021

Related content

View All

Anyone On Remicade Infusions? Will Medicare Cover Cost?

A myRAteam Member asked a question 💭
Upper Midwest

Remicade

A myRAteam Member asked a question 💭
Clermont, FL

Is Remicade Infusion A Good Transition After Unsuccessfully Trying Humira, Embrel, Rinvoq.

A myRAteam Member asked a question 💭
Nee york

Continue with Facebook
Continue with Google
By joining, you accept our Terms of Use, and acknowledge our collection, sharing, and use of your data in accordance with our Health Data and Privacy policies.
Lock Icon Your privacy is our priority.
Already a Member? Log in