I have Seronegative RA. It is more on the mild side but when I try to get off prednisone, I get a flare up. I just had another flare up last night, I saw my doctor today. I thought I would need to get fluid drained from my knee but there was no fluid, it was my tendon. Apparently I also have enthesitis. My doctor is suggesting that she treats this more aggressively. I have a few options to think about: One of my meds is methotrexate pill form. I could try the injection of methotrexate… read more
I actually had no prolems being methotrexate but I know some people struggle. I've started biologics too which work really well , again no problems
I was so scared before getting on Simponi injections and then Xeljanz. Xeljanz is a life saver for me. The steroids (prednisone) is a drug that I was on for many years and high doses at many times. After many years off of prednisone I am off of steroids (for now) but the pain is so great since I have been off of them. Simponi was the first biologic that I had ever been on. It never worked great for me So after a year, I was placed on Xeljanz which has helped so much. Xeljanz is in the family of DMARDS and not considered a biologic. Whatever it is, it's a life saver. If I can be of any help to you, please let me know.
I could not tolerate methotrexate. I've been on biologics for years. Different ones gave me different side effects. Enbrel works the best for me. Once you find a drug that works for you, you don't ever want to go back, no matter what the cost. It is scary that we have to take heavy drugs to have a somewhat normal life, but I would rather have a good quality of life while I'm alive. It is a give and take situation. I strive for a pain free life.
I’ve been on a number of biologics, my favorite being humira. But alongside the biologics I’ve always been on Methotrexate (25mg) - and I’ve been on methotrexate for now over half my life. Methotrexate calmed my severe RA down significantly, but not enough and we had to boost it with something else. On humira I almost went into remission and was able to reduce my methotrexate down to 18mg/week, but life has a way of presenting fun surprises, and it just stopped working for me basically. I’ve tried a number of different drugs since then - simponi, actemra, xeljanz, and now orencia (not working well enough). I had bad side effects on the actemra - my stomach acted up, as it did with xeljanz too (and xeljanz just didn’t help my joints enough). I also tried the injection form of methotrexate for a while and didn’t notice a significant difference.
Everyone reacts differently to these drugs - but the damage the disease is doing to your joints unmedicated is, in the long term, worse than what these drugs will do. I think others may disagree with me there, but I’d also like to raise the point that it’s about the quality of life too - I’d much rather enjoy the gift of time I have and I know that stronger medicines are going to allow me to do that.
I have cancer in my family too, and my mum’s mum passed due to complications related to her RA and suffered badly from it for most of her life.
I’m trying to say - life is short and special and we have the right to enjoy it! There are so many different options for medicines and being in the US we have wonderful access to healthcare - try it and keep a record of how you’re feeling. I used to literally rate each day 1-10 regarding pain and write down any weirdness, just in case they were side effects.
I also don’t know what kind of health insurance you have access to, but so many of these medications have special programs to make them more affordable and accessible. I worked for a nonprofit without good health insurance while I was on my last few months of humira and took advantage of the MyHumira program, which allowed me to afford the medicine. I know there was one for Actemra as well.
Hello, I am so sorry you are going through all this. I am seronegative as well and got diagnosed back in Sept. still trying to get managed. I am on plaquenil, Celebrex, prednisone and Arava. I tried one round of methotrexate and it made me super ill. I had to miss 4 days of work because of it. Now, my rheumatologist is trying to get my insurance to approve Xeljanz. I am nervous about moving up, but I just want to feel better. I’ve never had issues with my knees until November and just had one knee drained and I’m still waiting for the results. I hope you can find the right regimen that works best for you very soon. Hang in there❤️