I am seronegative. There are several people on here that are seronegative. RA is the inflammation of the synovial fluid around the joints. RA can attack other parts of the body with its inflammation. Osteoarthritis is the wearing down of the cartilage in the joints. OA is know as the "wear and tear" disease...time and joint stress. RA will usually affect the same joints on both sides. A lot of us on here have both OA and RA.

All of the above sounds horrible. My hands and wrist was the most painful. The hydrocloraquine celabrex and gadapintin has done wonders for me.

I am seronegative, too. Took a while to get a correct diagnosis because my labs did not show the markers that indicate RA. It took a pathology report of the synovial fluid drawn from my wrist during surgery to remove the pisiform bone that was digging into my tendons to confirm my diagnosis.

I'll keep you in my prayers. Love and hugs