Answer Summary

Members shared experiences of developing new side effects from Methotrexate after years of successful use, with symptoms including chills,... Read more

Members shared experiences of developing new side effects from Methotrexate after years of successful use, with symptoms including chills, headaches, body aches, fatigue, nausea, and liver issues emerging anywhere from months to seven years into treatment. Several members found relief through practical adjustments like lowering their Methotrexate dosage while adding Humira, switching to injections, or transitioning to Plaquenil alone, with one member successfully managing symptoms for over a year after their rheumatologist reduced their dose from 10 to 8 pills weekly. A recurring theme was the frustration that many medications eventually stop working or cause new problems over time, along with the importance of advocating for yourself by reporting changes to your doctor and requesting blood work to monitor liver function.