Mine doesn’t choose times. I notice that 2 weeks before my next infusion I start getting flare ups. Prednisone works great

Yes that has happen to me, It usually about 3 am and I can't lay back down for at least a hour or so.

Hang in there. Weight again is horrible but you have to heal the body. Let your doctor bring down the inflammation first.
I am fairly new to RA, my experience so far is that you have to rest when inflammation is ravaging your body.
The trick is to balance the rest and activity without in aggravating .
Every one has different family and work situation, so I hope you are able to get the support from family and work situation
For the weight gain, I was able so far to limit it 10 lbs by increasing fiber.

I save my Prednisone for flare ups. I've been just taking Ibuprofen and Duloxetine for several years. Just last month I broke my right arm and was told to stop the Ibuprofen because it slows down bone healing. Frankly, I haven't really noticed a difference. Taking acetamenophine doesn't do anything for pain. I can't do Tramadol, it just makes me very nauseated.

Mine starts when I go to bed so trying to fall asleep is awful am always tired and end up falling asleep through the day going back to work on the 1st august on a late shift xx