When I started plaquenil I was severely nauseated, constipated, barely able to eat for a year. Then I guess my body adapted and I am rarely nauseous and can eat. Something to talk with your doctor about. I also spoke with my primary doctor and rheumatologist.

I was on Plaquenil...generic brand...and it was helping..but had fast heart rate! That was scary. I am taking Symponi Injection and they seem to work along with low dose steroid..which I hope to stop. The one thing I do notice is really dry skin..especially my hands!

Years ago when I was trying various NSAIDS, when I was on Plaquenil, I got a rash up the back of my legs after 2 weeks with itching. I tried something else.

I am not on any NASIDS now at all. Only Methotrexate and Enbrel now.

Is there anything new in your job that may make you itch? I just thought of that. I got a office manager job straight out of college and when I started work I was so sick with a migraine and nausea, I had to go home at noon the first day. I was working in a photography studio. The next day I was fine until an hour after I got to work. Bingo, the migraine came right back. The smell of the processing chemical was so bad and I guess I was allergic to it. I was so excited about that job and had to quit. Just a thought. It can take a simple thing to make you have an allergy.🤗❤️

I am on both Sulfasalazine and Plaquenil. They had to decrease my dose of Sulfasalazine because I ended up with significant swelling to my ankles and feet.