Keeping in mind that Methotrexate is a low dose cancer fighting drug, try to stay aware of your digestion and take good care of your stomach even when you feel like you're tolerating it ok! It took me a good 90 days to figure it out.

MercedesL omg i thought it was just me with the leg cramps i knew i wasnt dehydrated i am also on leflunomide

I lost a lot of hair when I was on methotrexate, and it never fully grew back. I was pain free for the most part, but I am really attached to my hair, so I stopped that treatment, or any treatment at all, until last week. I am now on leflunomide, and the worst side effect so far is the calf cramps. Best of luck to you!

Hi Kimberly, thanks for your reply & sir taken so long to acknowledge, but have been really unwell. Excuse my ignorance but what is LDN? And yes I have to look at my diet but the problem is I’m unbelievably fussy about what I eat, extremely limited, by plant based you mean mainly base my diet around vegetables. Love some examples of the type of meals you mean, to see if I’m any chance of stomaching it!
Hope your well & life is treating you well!
Thanks Mark

Look into LDN! It’s life changing. Along with a plant based diet