Biologics can take a while to start working, usually 3 months. Once the biologics start working & your RA is under control, your doctor will probably start tapering you off methotrexate.

I am on both Orencia and Methotrexate for about 6 years, but have been on Methotrexate for many years.

I was on methotrexate for years then I started having fevers, which really left me on the side line and my rheumatologist changed it to Lefluetimide and I was on that for about 6 or 7 years then the current rheumatologist said that we should try Xeljanz without it and boy was I surprised to feel so much worse so rapidly. Needless to say I am back on it as that is what he told me to do if this were to happen.

I am on methotrexate and Enbrel. It takes time for blood levels to build up and these drugs to take effect. You may miss a dose or two and not notice any change in your condition because it takes a month or more after you stop taking them to feel any effects.

I've been on methotrexate for about 4 years but it wasn't working on its own so I now inject Simponi once a month as well and since doing that they seem to work perfectly together and I wouldn't be without it now.