I tried Methotrexate almost two years ago at the age of 31 when I had a severe onset of seronegative RA. My rheumatologist advises stopping methotrexate for a full year before trying to become pregnant. In retrospect, I wish I had not tried it. For me, it was even worse than the disease. I found no relief, suffered severe brain fog and fatigue, and was unable to work in my professional job.

I hope you find relief soon. The best advice I can give based on my experience is be patient and make sure you have a rheumatologist who takes an aggressive approach toward treatment. It took over a year to find the right drug for me (Enbrel) and to start getting my life back, but I was able to get things under control before the disease caused much permanent damage.

Thc I tried cbd but didn’t work for me. A low carb diet helps a lot also

I've been on methotrexate for 18 months since my diagnosis for RA. I was very worried about taking it as I had read so many bad things online. In fact I am doing really will on it, not taking any pain killers, so good luck.

I am on it now have been for about a month i was diagnosed around 5-6 months ago with RA. Did they start you on low dose? I have noticed a few days after i take the meds i feel a little sick and just out of it almost like pregnancy morning sickness i also cant eat but everyone is different i do have to say though dont get discouraged after the first time you take it i have learned thats when all the side effects are their worst BUT there is no other time like the first time or at least there wasnt for me it gets better every time i think your body adjusts to it which im glad i didnt give up on it now :)