I think it depends. This was unsuccessful with me, but I have heard very good results others have had with it. It’s got to be worth a try?

The methotrexate really helped me and I only had one side effect - I lost all my hair. Needless to say, I had to stop taking it and have yet to find a drug that works for my RA

moms started wuth 6 pills yellow once a week then 4 then 4 morning 4 bedtime

I've been taking methotrexate for nearly a year and a half. I started with 4 pills and have increased gradually until my current dose at 8 pills weekly. The main side effects I experience are a sensitivity to the sun (rash on chest and back if exposed for too long) chills (and I'm always cold anyhow as I also have Hashimoto's Disease), headaches, fatigue, and some damage to my hair. I was also prescribed folic acid to help combat the hair loss which I believe has helped, but instead my hair is a bit brittle. I have not noticed any significant improvement since being on this drug. I have extensive bone erosion in my hands and feet and the 2 ultra sounds I've had (a year apart; 1 before Methotrexate and 1 after a year of Methotrexate) show no positive change. I began Humira over the summer and have also not felt any improvement. I'm eager to see my doctor again in a few weeks to learn what he suggests next. I know a few people with RA who claim to have tried it all and have chosen to go a homeopathic route or simply not treat it at all as the meds weren't working and the side effects were worse than the disease.