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I have been on Enbrel almost 3 weeks and I do not feel any different. I don’t have any negative side effects either. I am also on methotrexate 10 tabs weekly. Concerned about being on 2 immunosuppressive drugs.
I took Embrel for 15 years and it worked great for me but it did not work immediately ( it had to build up in my system). In last year I was switched to Humira & HP Acther gel (due to uveitis ) so I am not having the same positive results as Embrel. Hope this helps you.
The twice a day was specifically to address the issue of it not lasting the full 7 days. It did help a lot but was not a long term solution for me. I think I did the twice a week for only about a year.