Oh yes the brain fog hangover was bad for me for first 2 days and could be nauseous at any time. Tablets were worse but injections not much better! Stick with it and see what happens as the weeks progress.

Thanks all! I will stick with it for the 20 weeks. The subq might be better. It is starting to ease the pain so I guess it's all about balancing good/not so good effects...

Methotrexate works well for a lot of people, I was just not one of them. I took it on Friday nights, because of work. On Saturday's I was nausea and could barley move off of the sofa. Made me so tired and sick. The on Sundays i still felt sluggish. I had to be on it for 3 month my doctors said in order to fail on it to do to a Biologic. Plus Methotrexate did not bring my levels down at all. Hugs

I got nauseated, my hair fell out, and I had nose bleeds and migraines the side effects were worse than the RA. I have a friend who takes it now and her RA doc put her on folic acid too, supposedly keeps you from getting sick. I wouldn't take that stuff again if the docs paid me, spent more time barfing and trying to stop migraines than anything else.