I’ve been on Simponi infusions for a couple of years now. They don’t put benedryl in mine and I am always so tired afterwards. I have mine early in the morning and stop for breakfast to take home as a treat. After I eat I always go to bed and sleep a few hours. I do find I am tired for several days.

I schedule my infusions later in the day because it makes me exhausted. I don’t think it is just because of the benadryl. I think it is normal for your body to be tired after the infusion. Hopefully you can plan ahead for easy dinners for the fam or appointments late in the day so you can rest. Good luck.

It was the same for me too. I have been off it awhile now.

I do the same thing. Not sure it's normal but I go through the same thing. I wish u luck