Answer Summary

Members shared mixed but mostly positive experiences with methotrexate for rheumatoid arthritis pain and inflammation, with many reporting... Read more

Members shared mixed but mostly positive experiences with methotrexate for rheumatoid arthritis pain and inflammation, with many reporting significant improvement when combined with folic acid and other medications like Humira, Enbrel, or Plaquenil, though some noted it worked better for certain joints than others or eventually stopped working altogether. Several members offered practical advice including always taking folic acid alongside methotrexate, considering B complex supplements to help with processing and energy, watching your diet, and being patient as it can take months to see full results. A recurring theme was that while methotrexate carries risks and side effects like feeling sick on injection day, hair loss, or organ concerns, many found the benefits outweighed the drawbacks, with one member sharing how it restored their ability to feed themselves after losing hand function.