Answer Summary

Members shared mixed experiences with methotrexate for RA, with many reporting it worked well for years without kidney problems, though some... Read more

Members shared mixed experiences with methotrexate for RA, with many reporting it worked well for years without kidney problems, though some experienced nausea that improved by switching from pills to injections. Several members offered practical advice including drinking plenty of water to protect kidneys, avoiding alcohol close to bloodwork days rather than completely, using high SPF sunscreen due to increased sun sensitivity, and following an anti-inflammatory diet while getting regular bloodwork every three months. A recurring theme was that while methotrexate is considered the gold standard and helps prevent joint damage, individual responses vary widely, so it's worth trying under medical supervision since many found great relief with minimal side effects.