I am currently on both. Started on plaquinil in 2017 so been almost 2 years now. Just started methotrexate in december. What scared me about mtx was that its low dose chemo. That scares me. But once you understand why it helps you... it helps because it slaps your immune system to calm the hell down for attacking all the good and bad cells since it doesnt know the difference. Telling your body to chill is its job.

and that mtx is the #1 go to drug for ra. It has years and years of research and a lot of info around the world. So many case studies and a lot of + results for ra.

What else scared me about it is I am only 36 and I havent 100% tossed in the towel of wanting kids yet. I want one. Im now lacking a husband (never had one) but when I was dating someone for thr last two years I was wanting to settle down. Now its back to square one. So on the kids front you have to come off mtx 6 months before trying for a baby. I was so Terrified of mtx to the point ir tears but asking questions in support groups has helped so much!!!

I take both with no problem. I also take Meloxicam and folic acid.

We do have to come to that place in the LORD.

I take both. I am ok

I have taken Plaquenil for 3 years because I didn't like the other side affects of methotrexate. But they all have them. With Plaquenil, you need to get an eye exam every year to check for changes in your sight. ( may cause blindness) But I feel it works as well as anything will. I am always in pain, sometimes it is worst than others. From what my doctor told me these 2 drugs are what they normally start you out on, they have been used for a long time. Hope this helps.