As someone who has tried most of the medications I have learned that time is short,damage happens fast, and all drugs are expensive. I would try one for four to six weeks. There should be some change. If nothing happens move on. It seems infusions give you the biggest bang for your buck and by passes your stomach . You don't want to ruin your stomach while healing your joints. Hope that helps. Good luck in your search.
Usually after about a month to six weeks, you should know if the medicine is working or not. And just because a medicine works well for you, doesn't mean it will work forever. Many times, after several years on one medicine, it will just quit being effective any more. Then you need to try another one. I started on Methotrexate, then added Plaquenil. I was on Reumicade for about four years, then Embrel for about six years. Then Humira for five years. Now I'm on Simponi Ariea. I've been on it for about a year and am probably going to change soon because it's not as effective for me as the others were!
I just started Humera and was told it could take 3-4 months before I see the results from it.
Sorry 4 to 6 weeks is not nearly enough time to know if a drug is working. Sometimes, the dosage needs to be increased or another med added. It took me almost a year before my rheumy was able to get the right dosage and medications for me to be out of pain and functional. Medrol to start with given to me by my GP ((end of JUly). then methotrexate which was continuously adjusted ((started in September), and finally Remicade in March). It wasn't until the summer that I realized I was doing much better.