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Does Biologic Meds Make You Feel Sick Like Chemo?

A myRAteam Member asked a question 💭
Pretoria, ZA

I am on methotrexate and it doesnt seem like its made any change yet.

February 27, 2018
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Reactions

Answer Summary

Members shared a wide range of experiences with methotrexate and biologics in response to the question about whether biologic medications... Read more

Members shared a wide range of experiences with methotrexate and biologics in response to the question about whether biologic medications cause chemo-like side effects, with many reporting that biologics like Enbrel, Humira, Orencia, Remicade, Actemra, and Rituximab produced little to no nausea and significantly reduced pain, though some noted fatigue, hair thinning, brain fog, or the challenge of self-injecting. Several members emphasized that methotrexate is technically a low-dose chemotherapy drug (classified as a DMARD) that can cause side effects including liver issues, hair loss, nausea, and cognitive fog, while biologics work differently by targeting specific immune cells and are generally better tolerated, though individual responses vary widely. A recurring theme was the importance of patience (as these medications can take weeks or months to work), close monitoring of side effects like liver function, open communication with rheumatologists about what is and isn't working, and the understanding that finding the right medication often requires trial and adjustment.

A myRAteam Member

I went off NY biologic because I ended up with swollen legs, chest pains and short of breath. My RA doc said the meds didn't cause it but when reading the side effects it was there so I went off. I also stopped my sulfasalazine for same reason. I hope I'm doing right thing. It seems the side effects are not worth it. I am doing Epsom salt baths, walking, compression stockings, hot tubs, saunas, healthy eating or trying lol and my orthotics. I hope this is going to help.
🙏❤️🙏

May 2, 2023
A myRAteam Member

It sounds like everyone is doing a good job taking care of yourselves and knowing when to adjust the meds or rest from them. Each of us have a tolerance threshold- some of us can endure higher pain and some cannot cope with a constant low level. Its difficult to know who will have positive or negative reactions to any med. Just as our physical appearance doesn't always reflect our burdens or pain level. At least I try not to look like or smell like an old twisted up dishrag. Some days it is what it is.

June 1, 2023
A myRAteam Member

Methotrixate is a very low dose of chemo, but I did have my hair thinking and of all things lost my eyebrows, eyelashes are thinner and hardly any body hair.... Lol at least I don't have to shave when I wear shorts

December 10, 2019
A myRAteam Member

I have had no real side effects. At my doc's recommendation, I have been taking folic acid to help counter any side effects. If you are taking oral methotrexate, take the folic acid (B vitamin) at the at the opposite time of day as the methotrexate since they compete with each other.

March 7, 2018
A myRAteam Member

I feel like I'm in remission

September 29, 2023

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