When I was first diagnosed I was on 60 mg of @prednisone and also @methotrexate. Initially I was on low doses of @methotrexate, but over time the dose needed to be increased for me to feel better. Prior to discontinuing it, the dose was split into morning and evening hoping that I would absorb it better also because of the higher dose. My doctor recommeded i start on biologics. I no longer take @methotrexate, am off the @prednisone and only use @Enbrel. I was afraid, too, but in retrospect I am glad I agreed to use @Enbrel. I feel so much better, my lab test results are much better; I always tell the doctors and pharmacy people that i have my life back. I know that the early days of diagnosis and treatment are rough. Be open to what will help you feel better. Wishing you well.

I had problems with oral methotrexate and now use injections and these work fine. Not sure they are helping with pain at all though but all have no side effects.

I have been on Enbrel for 4 years. Doing great & no side effects.

Same with me. It quit working for me after about seven months. I ended up in ER with respiratory failure and almost died. Tests showed I had an allergic reaction to the methotrexate. There are side effects with most all the RA drugs. You have to weigh out the pros and cons.

Yes, that's how it was for me in the early days prednisone and methx, then Enbrel which worked wonders for years. now my Rhemy thinks i may have build up a tolerance so we will try something else. I hope it works.