I got muscle cramps so bad in my calves that I thought someone was trying to crush my bones. Another time cramps and spasms at the same time in both legs I couldn’t walk. I went off the methotrexate and they all stopped. I do know that RA and or its medications will deplete your potassium and magnesium. Daughter in law is a nurse and suggested I take these two supplements. I have been and I haven’t been getting the cramps in my back around my ribs any longer. Those cramps still continued after I stopped the methotrexate. I am now starting my own therapy of nothing but natural supplements. I’m done with all the side effects and chemicals that are in these medications.

As I have only been diagnosed this Feb I am still new to the drugs, however I have for about 6 yr had horrible cramps in my calf muscle but only in right leg, as for muscle spasms and flickering nerves like a butterfly in my back or front off thighs I have had for such a long time, I'm also started t feel my eyelids twitch, so for me the meds are not to blame

I shook so badly that I needed to support my elbows on the table to drink coffee without spilling it. This situation feeaked out my sons and husband. All that shaking stopped after I stopped all the mdicine in Feb 2012. 10 moths down the line I could even put nail polish on my nails without painting my whole fingertip. It took a while for all the chemicals to get out of your system. But, blood tests confirm that I am in remission ever since and the docter told me that the using of the drugs for 14 years might be the reason for the remission. Yes I still have pain because of the damage in my joints, but no new activity.

I was diagnosed with RA in April 2017. I have bouts with muscle spasms and cramps to my feet and toes and also my hands. I can make a wrong move and the muscle spasms attack something fierce, especially to my back, shoulders and legs. Never experienced the shakes. Good luck to you!