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Does Methotrexate Wear Off In Between Doses?

Does Methotrexate Wear Off In Between Doses?

Hi everyone,
I take methotrexate (orally) on Friday nights. From Saturday to Wednesday, the pain is a lot less. I can also go down to 15mg of prednisone. By Wednesday night, I can already feel a difference and I need to go back up to 20mg of prednisone on Thursday morning or else I wouldn’t be able to put any weight on my foot. Is it possible that the methotrexate is wearing off?
Thank you!!

A myRAteam Member said:

Yes, until your body regulates it

edited, originally posted almost 4 years ago
A myRAteam Member said:

Biologics are medications used to treat RA. I'm sure you've see the ads on TV for Humira and Enbrel. They are sometimes necessary to take in addition to methotrexate to treat the RA

posted almost 4 years ago
A myRAteam Member said:

Yes! I take it Saturday morning and by Wednesday I start to feel fatigue and pain again. Once I take it on Saturday it feels like it takes a day to get in my system again. Will talk to my doc about increasing the dosage...

Fell well soon!

posted almost 4 years ago
A myRAteam Member said:

The trexate is working... Yes, sometimes it slows down. It takes two weeks to flow out of your system. I have to take mine weekly as well and I find that by Wed, I'm ready for my Friday dosage.
How do you use prednisone for so long? It messes with my muscle functions...especially my bladder and kidneys? My doctors took me off after two weeks!!

posted almost 4 years ago
A myRAteam Member said:

Oh and the main point in my post the necrosis was caused by long term use of steroids

posted almost 4 years ago
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