I used to be on Methotrexate. If you investigate it, Methotrexate in a mild form of a drug they use for chemotherapy. Studies show that chemotherapy drugs can cause that fuzziness or "chemotherapy brain." I know as an IT professional, I see how thinking clearly can be difficult sometimes.

I too was on Methotrexate. It definitely gave me brain fog and it made me so tired I can barely walk around after 3 in the afternoon. I had to lay down on the sofa everyday. I was glad I got off of it.

The brain fog is one of the many symptoms of RA. Before i got RA , i had a near photographic memory. When the RA symptoms started , so did the brain fog. I thought i was losing my mind. I could no longer multi task & could barely remember my own name. Methotrexate makes it even worse because it makes your immune system so weak. Take folic acid & a good multi vitamin and get plenty of sleep each night and lay down in the afternoon. Even if it's only 15 minutes it will help.

Hi ...it's called the Methotrexate fog...you feel a little wooly brained.

I have been on methotrexate a long time, non problems until I started taking myloxicam also, now I'm very confused at times and not thinking clearly