Take it with the metho and I always took it at night so I could sleep through the nausea. The folic acid just helps with the hair loss you might experience.
Many metho works for...but, many it doesn't. I was the latter. Good luck!

Take it every day. It is to help strengthen your immune system so you won't get too weak.

Daily

I was told everyday

I have taken folic acid every day since I began methotrexate and that's been 5 years now.