I think fatigue is a side effect of most of these are a drugs. The best thing to do I found is to eat anti-inflammatory foods get lots of rest and exercise.

I have been taking it since 2012,best one that works for me. No issues with it.

I take leflunimide with Simponi...methotrexate...I just couldn't tolerate...but this ...I've really have no side effects!

It's interesting about the frizzy hair. I thought it was just the humidity outside but my hair is really frizzy also. It's usually really straight. I take leflunomide and Orencia

No problems for me either.