It worked quite well. Once you get over the initial hesitance of injecting yourself, it's no biggie. The first two or three, the nurse did at my rheumies,

I was helped by Cimzia. I really noticed a difference. However, I kept getting minor infections (like upper respiratory etc.) and doc thought it was the cause and took me off and that was the last one I took until he recently prescribed xeljanz. Regarding injection, I always injected into my stomach and surprisingly it didn't hurt me at all! I carry some extra weight around my middle which is why it helped I guess. But when I gave it in the thighs I got bruises. Initially, I thought that I would prefer the location as the thoughts because something about giving it in my stomach made me scared. But I was so glad after I tried it and no pain or bruising. The Cimzia injections that I had were less painful for me because unlike humira autoinject hurt.

The needle didnt hurt going in but the medicine did going in