I was diagnosed as Seronegative. My RA factor and sed rate were low, but my C-reactive protien was peaking the scale. I have been on mostly all the biologics sometimes for long periods of time. The right combination of meds should help, it just getting there. I have taken methotrexate since the beginning, about 15 years and have to increase and decrease every now and them, but overall i am managing well. Hang in there.

I found your post as I was searching for information about Seronegative RA. I am waiting for a diagnosis, but my Dr. believes it is RA. My major symptoms were swollen, stiff and painful ankles. The swelling was fairly brief and managed with Celebrex. Since then I have stiffness and some pain but virtually no warmth, no redness and no further swelling. My feet and ankles are the worst, but my fingers and wrists are sometimes affected, and on occasion my elbows. I am also plagued by fatigue. My ESR was a 24, with up to 30 being normal at my lab. I would be interested to see how you are doing now, since this post is a couple of years old. It was helpful to find someone who has similar symptoms to me!

Thank you!! So nice to find someone with the same strange land as me 😊 Do you have swelling or just pain and fatigue?

I also have your symptoms and although I have had RA for 16 years my joints are not really deformed. I have read though, that if one is sero-negative, that is one of the benefits. When I first got RA my hands were very swollen, but over the years that has gone down. I am taking anti-inflammatories, but no DMards, and I refuse to take prednisone because of the side effects.