I too have leg cramps but I have been on MTX for almost 6yrs now. The leg cramps started about 9 months ago when I started having some other issues (swollen glands, major fatigue, horrid pains that would come and go) The cramps dont just happen in my legs, I get them in my stomach too. It turned out I had developed anemia, and vit D deficiancy (all RA caused). Since starting Iron and Vit D 3 months ago the cramps have gotten a little better but the doc says it could take 6months to feel the full effects of the treatment. You shoudl get tested for Anemia and Vit D.

I just posted a similiar question about aching legs. I too take MTX and have been for 2 years. As soon as insurance approves I'm going to switch to Xeljanz. I hate that you are experiencing the cramps too. I have doubts that it's associated with MTX (since I've been on it so long and this is the first time this has been a problem.

Wow! I had no idea that my low vitamin D was from the RA! I take liquid Solgar and if I'm careful about taking it everyday it stays near normal range. Now I won't stop! Thank you

Methotrexate, definatelly day after dose I can get bowel dumping. It usually only causes it for one day.

Check out net on RA/A issues U.T.I etc..I use laser for all inflam etc...