I've had JRA since age 2 and have never had a RF. There's also no doubt in any doctors mind that it's RA. Don't feel bad if you have to keep switching doctors until they get it right!

I am seronegative and my doctor advised me that if I ever had to change doctors to be very careful. Many rheumatologists dont believe in seronegative and will take you off all your meds and start the diagnosis process all over again.

I am seronegative too. All my blood work comes back normal..........but on ultrasound I have tons of joint inflammation and of course pain and swelling.

Same here. My first rheumatologist said that there is always a small percentage of people with RA are negative. She said that there are multiple types of arthritis other than the two basics (osteo and rheumatoid) also and I was diagnosed as poly-arthritic. And it seems like a lot of people with RA also develope fibromyalgia as well.

KristinaClay, that is what happened to me. My first rheumatologist left, and the next one took me off all medications. He did the Vectra test which showed as moderate. At that point he put me on a biologic and Methotrexate. I was doing much better. He did another Vectra test and it showed on the high side of mild. He then took me off of everything and acted like nothing was wrong, but wanted me to keep coming back. The next one, didn't question when I told her that I had been diagnosed as seronegative. She knew both doctors that I had seen before and with my symptoms, immediately got me back on meds. Then she left and there are very few rheumatologists in my area, so I have just been suffering for a long while. Sometimes it's bad, sometimes not so much. I really need to find another one soon, but I am concerned that I can't find one who agrees with the seronegative diagnosis.