You can take up to but no more than 1200mg's day, without harm. Anything over that can cause damage to your liver. I tell my patients to take no more the then 1000, "if" needed.

thanks for the tip. sometimes I have to supplement with Tylenol for Arthirits which is 850. Aleve makes
holes in my tummy.

I am slowly decreasing the mtrx due to horrible side effects. I also keep a detailed daily journal of any aches, pains, thoughts that I can refer to. I am doing this on my own; doctor does not know. I use the doctor
as a reference if I don't understand something. We don't really see eye to eye so I don't tell her. I seriously doubt if my doctor takes the same meds so she has not idea of the horrible side effects. Everytime I tell her
something she insists it is not possible. Good Luck. My wish grandmother taught me at 5 yrs old...to thine own self be true. !!

Ive had a very bad stomach due to meds please be careful

The most important thing to remember about Methotrexate, a biologic, or similar medication is the primary purpose they serve is to prevent joint damage. There is even the possibility of them putting you into remission ... some have even experienced this permanently. The success stories come during early diagnosis and treatment. So, yes, there is some help with the pain but never forget the meds are to treat the disease. I would coordinate your meds/treatment under the guidance of your rheumy. Sounds like you have to potential to have what we would all like ... remission. All the best. I hope you are able to escape the clutches of this nasty disease. Hugs. =^^=