I was told it may take 3 to 6 weeks of treatment before you start to experience a therapeutic response to methotrexate, then up to 12 weeks or more for the full effect to be achieved. It took about a month for me.

When I began taking methotrexate I was told it would take about 8 months for it's full effectiveness.

I was on methotrexate but I'm no help to you as it didnt work for me...I wish you all the luck that it does for you!!!

It can take awhile to take affect. Are you one anything else with it such as steroids? If not you might ask your rheumy about adding them or a biologic. The methotrexate might not be enough to get you under control.

I was told the same as Breeze but to be honest l dont think its working, l have so many pain killers its mad on an average day l take between 21 - 29 tablets a day on a methotrox day it can be nearly fourty tablets hey who needs food when l have so many yummy tabs !! I also have fibro and other stuff xx