Answer Summary

Members shared their experiences managing seronegative rheumatoid arthritis, emphasizing that treatment truly is trial and error since... Read more

Members shared their experiences managing seronegative rheumatoid arthritis, emphasizing that treatment truly is trial and error since bloodwork often remains normal despite active disease visible on imaging like MRI. Several members described their current medication combinations, including methotrexate (oral or injectable), biologics like Humira and Orencia, diclofenac, and low-dose prednisone, noting that everyone responds differently and it can take multiple attempts to find what works. A recurring theme was the frustration of having pain and inflammation that doesn't show up in standard blood tests, the overlap of symptoms with conditions like lupus and fibromyalgia, and the importance of advocating for imaging and working closely with a rheumatologist to adjust treatment until relief is found.