I was started on methotrexate when I was first diagnosed in March 2014. It took about 3 months to start working. I had Plaquenil added about 6 months later and then Humira added shortly after. The Plaquenil initially gave me a tingling feeling and some problems with gas and diarrhea. That went away...even after my gallbladder was removed! Overall, the combination of meds I'm on helps a lot. I definitely know when it's time for the next dose so I know they work! I go to the ophthalmologist once a year. I haven't had any problems so far. He said it's usually after long term use...like 25 years. I still am having flares...especially with my hips. I'm not sure if any combination of meds will stop all the deterioration...but I do think the Plaquenil helps. It's also less expensive.

I was on plaquenil when I was first Dx.. its the first line of treatment. Unfortunately, my RA was too advanced and I progressed to methotrexate and then biologic TNF modifier, and then biologic B cell blocker. My mother developed RA as well and is doing fantastic on Plaquenil. She definitely notices it was when she doesnt take it! Make sure you are going to the appointments to get your eyes checked.

It has helped me significantly.

Thank you. Yes my doctor advised it could affect my eye sight. I just got my information under control in my left eye. So this side affect is discouraging.